Posted in Volume 15 - Number 2
MUHAMMAD ILTAF, KHEMOMAL A. KARIRA, NUDRAT A. ZUBERI, SALEEM UL HAQ, JAGDESH, HARESH
Abstract | Full Text PDF
BACK GROUND: Prostate cancer is becoming an important public health care problem and is now the second leading cause of death in men from cancer. There are various biochemical factors which are related to prostate cancer. In this study we have found out the relationship of serum insulin, IGF-1 and PSA with prostate cancer
AIM OF THE STUDY: To evaluate the serum level of insulin, insulin like growth factor 1 (IGF-1) and prostate specific antigen (PSA) in prostate cancer patients and normal control subjects and to compare/correlate the values of these parameters between control and patient groups.
STUDY DESIGN: This case control study was carried out in the Department of Biochemistry, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi in collaboration with Urology and Radiotherapy units of JPMC Karachi
SUBJECTS AND METHODS: A total of 70 subjects were included in this study. 35 diagnosed cases of prostate cancer were mostly taken from Urology and Radiotherapy units of JPMC and 35 age matched control subjects were taken from general population for comparison. Most of the study subjects were above 50 years of age. Written consents were taken from the subjects prior to blood collection.
RESUTS: Our study showed highly significant increase (P‹ 0.005) in serum insulin, IGF- 1 and PSA in patient group when compared to control group.
CONCLUSION: Our study suggested an association of increased levels of insulin, IGF- 1 and PSA with prostate cancer. PSA is a diagnostic marker for prostate cancer but IGF- 1 and insulin are also handy for the diagnosis of prostate cancer. Therefore, it is concluded that along with PSA, IGF-1 and insulin should be routinely done as diagnostic tools for prostate cancer.
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