Posted in Volume 15 - Number 3
RAFAT MURAD, KHEMOMAL A KARIRA, MURAD QADIR
ABSTRACT | Full Text PDF
OBJECTIVE: To assess the association of bone mineral density with urinary hydroxyproline creatinine ratio and serum estrogen in pre and postmenopausal women.
DESIGN: Cross sectional study.
SETTING: The study was carried out in Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC) Karachi.
METHOD: Females (n = 90) were assessed with measurements of Body Mass Index (BMI), Menstrual History, 24 hour urinary excretion of hydroxyproline Creatinine ratio, serum estrogen. Bone Mineral Density of Women was evaluated by Dual Energy X - ray Absorptiometrey (DEXA) and its association was analyzed with urinary hydroxyproline creatinine ratio and serum estrogen.
RESULTS: A significant number (44%) of postmenopausal women were found to be osteoporotic while 48% were osteopenic. Bone Mineral Density was normal in premenopausal women. The mean urinary hydroxyproline creatinine ratio increased in postmenopausal women (23.59 mg/gm creatinine) compared to premenopausal women (13.62 mg/gm creatinine). Serum estrogen was significantly decreased in postmenopausal women (45.082 ± 3.44 pg/mi) compared with (106.41± 6.69 pg/mi) in premenopausal women.
CONCLUSION: This study showed that there is growing incidence of osteoporosis with increasing postmenopausal years. Twenty four hours urinary hydroxyproline creatinine ratio is directly proportional whereas serum estrogen is inversely proportional to bone mineral density.
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