Posted in Volume 16 - Number 1 Suppl
MANZOOR ALI PHULPOTO, M. SHAFIQUE KHUHAWAR, JAVED SIYAL, NADEEM RIZWI, NANIK RAM, NAHEED SHAIKH, SULTAN AHMED
ABSTRACT | Full Text PDF
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality through out the world. Acute exacerbations are frequent in severe COPD.
OBJECTIVE: Our aim was to investigate the possible relationship between impairment of lung function measured by forced expiratory volume in one second and bacteria isolated during acute infective exacerbation of COPD.
STUDY DESIGN: cross-sectional descriptivestudy.
SETTING: This descriptive study was conducted in department of pulmonology Jinnah Postgraduate medical centre Karachi from August 2003-August 2004.
MATERIAL AND METHOD: All those hundred patients admitted in ward with acute exacerbation of COPD and have enough sputum production for microbiological culture and were able to perform lung function test to evaluate FEV1 were included in the study.
RESULTS: Lung function tests revealed 26 patients had FEV1 of >50 %( stage 1), 27 patients had FEV1 of 35%-50 %( stage II), and 47 patients had FEV1 of <35 % (stage III). Bacteria isolated were classified as Streptococcus Pnuemoniae and other Gram positive Cocci (Group I), H-Influenzae and Moraxella cattarhalis (Group II) and Enterobactericae and Pseudomonas spp (Group III). For all above patients together the most frequently isolated bacteria were group 3(45%).three groups of bacteria were unevenly distributed among three stages of severity of lung function(p-value =0.001)
CONCLUSION: There is a correlation between deterioration of lung function and bacteria isolated from patients with acute exacerbation of COPD. In patients with FEV1 of<35% Enterobactericae and Pseudomonas spp were the predominant bacteria, this should be considered when establishing an empiric antibiotic treatment for Acute exacerbation of COPD and this help predict prognosis in AECOPD.
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