Posted in Volume 16 - Number 1 Suppl
SHAKIRA PERVEEN, JEHAN ARA AINUDDIN, SHAISTA NAZ
ABSTRACT | Full Text PDF
OBJECTIVE: To assess tocolytic efficacy & safety profile of Glyceryle trinitrate (GTN) in threatened preterm labour.
STUDY DESIGN, SETTING & METHODS: Quasi-experimental study carried out at a tertiary care private hospital from Jan 2008 – Dec 2008. Fifty pregnant women at 28- 34 weeks of gestation underwent GTN (a nitric oxide donor) short-term tocolysis for threatened preterm delivery. A 10 mg/ 24 hr Nitroderm transdermal patch was placed on anterior abdominal wall & replaced by second patch of same dose after 24 hours.Cessation of contraction, prolongation of gestation & side effects of agent was observed.
RESULTS: Out of 50 experimental subjects 66% were more than 25 years, 78% were para 2-3, 88% were between 28- 30 weeks of gestation. Around 46% had complete cessation of contraction within 2 hours & 64 % had successful tocolysis of 48 & more than 48 hours. Out of them 12% were with previous uterine scar. Commenest side effect (40%) was maternal headache. None of them had fetal side effects.
CONCLUSION: The management of threatened preterm delivery with first line tocolytic therapy can prolong gestation. There is no clear first line tocolytic agent, should individualized & based on maternal condition, potential side effects & gestational age.
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