Posted in Volume 16 - Number 1 Suppl
ABDUL RASHID SURAHIO, ALTAF AHMED TALPUR, HAFEEZULLAH ABRO, ABDUL JABBAR MIRANI, IFFAT FATIMA, ASADULLAH KHAN
ABSTRACT | Full Text PDF
OBJECTIVE: To determine the effectiveness of per-operative antibiotic prophylaxis in reduction of post operative wound infection in clean contaminated procedures.
PATIENTS AND METHOD: This experimental randomized controlled trial study was conducted in general surgery department, Jinnah Postgraduate Medical Centre, Karachi, Pakistan, from 1st November 2005 to 30th October 2006. Patients admitted for elective clean contaminated procedures between the ages of 13 and 60 years irrespective of the gender were included. Patients with high risk of infection were excluded from the study. Total 400 subjects were divided into group A (200) and group B (200) by randomization for one day and five day prophylactic therapy respectively.
RESULTS: Over all infection frequency in group A and B was 12(6%) each. On the other hand, in clean contaminated procedures, 6(6.7%) infected in group A, and 5(4.5%) in group B (OR 1.2, 95%CI 0.4-4). In Group A, culture was positive in two patients, Staphylococcus Aureus sensitive to Cefuroxime while in Group B, four patients had single stitch focus infection culture positive, Staphylococcus Epidermids, sensitive to Cepharadine. Culture sensitivity results were not significantly different between two groups (Z-test, two independent samples for proportion, p-value>0.05).
CONCLUSION: Single dose antibiotic prophylaxis is as effective as 5 days’ conventional therapy in clean contaminated procedures.
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